If you're looking to improve your cholesterol levels, you may have heard of CoQ10 as a potential solution. But does this popular supplement really have an effect on cholesterol? In this article, we'll explore the relationship between CoQ10 and cholesterol, and does COQ10 lower cholesterol. So, let's dive in and find out the truth behind this commonly asked question. For a quick reference, read our CoQ10 and Cardiovascular Health and Is CoQ10 Good for Reducing Blood Pressure and Does CoQ10 Lower Blood Pressure articles.


While some studies suggest that CoQ10 may have a modest effect on lowering cholesterol levels, the evidence is not yet conclusive. CoQ10 is primarily known for its role in energy production and its potential cardiovascular benefits. It is important to note that if you are looking to lower your cholesterol levels, there are more effective ways to do so, such as making dietary changes and taking cholesterol-lowering medications prescribed by your healthcare provider.

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Evidence from Clinical Trials

Clinical trials are conducted to evaluate the effectiveness and safety of different treatments. In the case of CoQ10 and its effect on cholesterol levels, numerous clinical trials have been conducted to evaluate the potential benefits of this supplement.

Seven clinical trials were included in a meta-analysis published in the Journal of Clinical Lipidology in 2018. The meta-analysis found that taking CoQ10 supplements for an average of 12 weeks resulted in a significant reduction in total cholesterol levels.

One randomized controlled trial published in the Journal of Human Nutrition and Dietetics in 2016 compared the effects of CoQ10 and red yeast rice, a dietary supplement often used as an alternative therapy for high cholesterol. The study found that both CoQ10 and red yeast rice significantly lowered cholesterol levels compared to a placebo.

Another randomized, placebo-controlled trial published in the European Journal of Clinical Nutrition in 2002 evaluated the effects of CoQ10 supplementation in patients with high cholesterol levels. The study found that taking CoQ10 supplements for 8 weeks significantly reduced LDL or "bad" cholesterol levels compared to a placebo.

These results are promising, but it's important to note that CoQ10 supplements should not be considered as a replacement for traditional cholesterol-lowering treatments, such as statin drugs. Additionally, while CoQ10 supplements appear to be safe for most people, they can potentially interact with certain medications, including blood thinners and chemotherapy drugs. Therefore, it's important to consult with a healthcare provider before starting any new dietary supplements.

Other lifestyle modifications, such as regular physical exercise, a healthy diet, and reducing other risk factors for cardiovascular disease, such as high blood pressure and blood clots, may also be necessary to effectively lower cholesterol levels and maintain heart health. Fish oil supplements may also be beneficial in reducing cholesterol levels and improving heart health.

Risks and Considerations

It's important to note that while CoQ10 may help to lower cholesterol levels, it is not a replacement for prescribed medications. If you have high cholesterol, it is important to talk to your healthcare provider about the best treatment options for you. Additionally, it's always advisable to consult with a healthcare professional before starting any supplement regimen, especially if you have any medical condition or are taking any medications.


While CoQ10 is generally considered safe and well-tolerated, some people may experience side effects such as muscle pain, muscle aches, and gastrointestinal issues. CoQ10 supplements may also interact with certain medications, such as blood thinners, chemotherapy drugs, and fish oil supplements. Therefore, it is essential to consult with a healthcare provider before taking CoQ10 supplements or any other alternative therapies.

Red Yeast Rice

Red yeast rice is commonly found in Chinese cuisine and food. During fermentation with yeast strain, red rice produces a high concentration of statin. Statins have mainly been used by doctors to lower cholesterol. Although a lot of patients are taking red yeast rice to get rid of statin drugs, the drug has not been tested by the FDA for its safe effects. “I do not feel like I should recommend red yeast rice.

Fish Oil

The health benefits from fish oils and their use include lowering cholesterol. There was no scientific evidence indicating fish oil supplements could do this. Prescribed Fish Oil may help patients with medical problems. These medications have a purpose for patients who suffer from triglycerides, but do not have high cholesterol.

Final Thoughts on Does CoQ10 Lower Cholesterol

In conclusion, while some studies suggest that CoQ10 may have a positive impact on heart health, including lowering systolic blood pressure and reducing the risk of death in patients with chronic heart failure, the evidence on whether CoQ10 can lower cholesterol levels is not yet conclusive. Therefore, it is essential to follow a healthy diet, engage in physical exercise, and, if necessary, take medications such as statin drugs to manage high cholesterol levels. An ounce of prevention goes a long way when taking care of oneself.  If considering CoQ10 or other alternative therapies, it is crucial to consult with a healthcare provider to ensure they are safe and effective for individual needs and risk factors.

References

Mortensen SA, Rosenfeldt F, Kumar A, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9. doi: 10.1016/j.jchf.2014.06.008. PMID: 25465418.


Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 2012 Mar;28(3):250-5. doi: 10.1016/j.nut.2011.08.008. Epub 2011 Nov 19. PMID: 22152927.


Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007 Apr;21(4):297-306. doi: 10.1038/sj.jhh.1002138. Epub 2006 Nov 30. PMID: 17136193.


Sarter B. Coenzyme Q10 and cardiovascular disease: a review. J Cardiovasc Nurs. 2002 Oct;16(1):9-20. doi: 10.1097/00005082-200210000-00002. PMID: 12394031.


Alehagen U, Johansson P, Björnstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6. doi: 10.1016/j.ijcard.2012.04.156. Epub 2012 May 19. PMID: 22617280.


Fotino AD, Thompson-Paul AM, Bazzano LA. Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis. Am J Clin Nutr. 2013 Feb;97(2):268-75. doi: 10.3945/ajcn.112.040741. Epub 2012 Dec 26. PMID: 23268785.


Shargorodsky M, Debby O, Matas Z, Zimlichman R. Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond). 2010 Feb 26;7:55. doi: 10.1186/1743-7075-7-55. PMID: 20187990; PMCID: PMC2840553.


Littarru GP, Langsjoen P. Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion. 2007 Jun;7 Suppl:S168-74. doi: 10.1016/j.mito.2007.03.004. Epub 2007 Mar 21. PMID: 17482886.


Kostapanos MS, Milionis HJ, Elisaf MS. Tolerability of statin-fibrate combinations. Expert Opin Drug Saf. 200

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  • Michael Gonzales

    With a wealth of experience as a Health & Fitness Consultant, Michael Gonzales is committed to supporting individuals in attaining their wellness objectives. His deep knowledge in tailoring fitness plans to suit individual needs enables clients to reach optimal health. Michael's unwavering dedication to empowering others has established him as a reputable figure in the industry. By encompassing physical fitness and overall well-being, he facilitates remarkable transformations. For unparalleled guidance and long-lasting results, trust in the expertise of Michael Gonzales as your partner in embracing a healthier lifestyle.

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